References – Pharmacology, Drug Discovery

Bryson, G., Reynolds, R. W. (1981) Effects of adrenocortical stress responses and metabolic functions during and after long-term administration of dexamethasone to adult Evans-Long rats. Res Commun Chem Pathol Pharmacol 34(2): 267-286.

Catapano AL. Ezetimibe: a selective inhibitor of cholesterol absorption. Eur Heart J Supplements. Vol. 3 (Suppl) 2001

Chow, F. H., Hamar, D. W., Boulay, J. P., Lewis, L. D. (1978) Prevention of oxalate urolithiasis by some compounds. Invest Urol 15(6): 493-495.

Clauberg, M., Smith, C. B., Dang, T., Sodoloff, L., Joshi, J. G. (1994) Effects of chronic dietary aluminum on local cerebral glucose utilization in rats. Neurobiol Aging 15(5): 657-661.

Coletti AE, Vogl HW, Rahe T & Zambraski EJ. Effects of acetaminophen and ibuprofen on renal function in anesthetized normal and sodium-depleted dogs. J Appl Physiol.1999;86:592-597.

Conde, K. et al. Hypocholesterolemic Effects of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors in the Guinea Pig. Biochemical Pharmacology, Vol. 58, pp. 1209–1219, 1999.

Cox, S. R., Harrington, E. L., Hill, R. A., Capponi, V. J., Shah, A. C. (1985) Bioavailability studies with ciglitazone in beagles 1: Effect of a meal on the bioavailability of 3 ciglitazone dosage forms. Biopharm Drug Dispos 6(1): 67-80.

Davis HR, Pula KK, Alton KB, Burrier RE & Watkins RW. The Synergistic Hypocholesterolemic Activity of the Potent Cholesterol Absorption Inhibitor, Ezetimibe, in Combination With 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors in Dogs. Metabolism. 50:1234-1241. 2001

DiBattista, D., Helm, K. J. (1985) Dietary self-selection in insulin-injected hamsters mesocricetus-auratus. Physiol Behav 35(1): 1-8.

Dixit, R., Coleman, J. B., Thomas, J., Adams, S., Grossman, S., Keenan, K. P. (1996) Effects of dietary (caloric) restriction on the toxicity, metabolism, and toxicokinetics of pharmaceutical agents in Sprague-Dawley rats: Beneficial role of reduced oxidative stress. Toxicologic Pathology 24(6): 787.

Dixit, R., Coleman, J., Cook, W., Soper, K., Mattson, B., Keenan, K. (1996) Comparison of the effects of ad libitum (AL) overfeeding and dietary restriction (DR) on toxicological and pathological biomarkers of survival, proliferative and degerative diseases in Sprague-Dawley (SD) rats. FASEB Journal 10(3): A182.

Elrod, S. V., Leslie, S. W. (1980) Acute and chronic effects of barbiturates on depolarization-induced calcium influx into synaptosomes from rat brain regions. J Pharmacol Exp Ther 212(1): 131-136.

Gascon-Barre, M., Vallieres, S., Huet, P-M. (1986) Influences of phenobarbital on the hepatic handling of [3H] vitamin D3 in the dog. American J of Physiology 251(4): G627-635.

Gold, R. M., Klein, M. G., Ringuette, B. A., Lowell, B. B., Katz, R. (1979) Non-effect of Massachusetts cement kiln dust upon the food intake, body weight, or activity of female rats. Pharmacol Biochem Behav 10(1): 1-3.

Goldman, M., Doering, G. J. (1979) The effect of dietary ingestion of oxalic acid on thyroid function in male and female long-evans rats. Toxicol Appl Pharmacol 48(3): 409-414.

Goldman, M., Doering, G. J., Nelson, R. G. (1977) Effect of dietary ingestion of oxalic acid on growth and reproduction in male and female Long-Evans rats. Res Commun Chem Pathol Pharmacol 18(2): 369-372.

Granados, H. (1980) Vitamin E and methylene blue in the prevention of abnormal pigmentation in the seminal vesicles of the castrated golden hamster. Arch Invest Med (Mex) 11(3): 361-375.

Hancock, A.A. et al. Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. European Journal of Pharmacology 487:183–197, 2004.

Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology 462:125–132, 2003.

Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolution X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and Toxicological Methods 47: 99– 106, 2002.

Howell, T. H., Reddy, M. S., Weber, H. P., Li, K. L., Alfano, M. C., Vogel, R., Tanner, A. C. R., Williams, R. C. (1990) Sulfadiazines reduce gingivitis and plaque formation in beagle dogs. J Clin Periodontol 17(10): 734-737.

Jasmin, G., Proschek, L. (1998) Effect of orotic acid and magnesium orotate on the development and progression of the UM-X7.1 hamster hereditary cardiomyopathy. Cardiovascular Drugs and Therapy 12(2): 189-195.

Kanarek, R. B., Ho, L., Meade, R. G. (1981) Sustained decrease in fat consumption produced by amphetamine in rats maintained on a dietary self-selection regime. 14(4): 539-542.

Kanarek, R. B., Marks-Kaufman, R., Ruthazer, R., Gualtieri, L. (1983) Increased carbohydrate consumption by rats as a function of 2-deoxy-D-glucose administration. Pharmacol Biochem Behav 18(1): 47-50.

Kanarek, R. B., Mayer, J. (1978) 2-Deoxy-D-glucose induced feeding: Relation to diet palatability. Pharmacol Biochem Behav 8(5): 615-617.

Kanarek, R. B., White, E. S., Biegen, M. T., Marks-Kaufman, R. (1991) Dietary infulences on morphine-induced analgesia in rats. Pharmacol Biochem Behav 38(3): 681-684.

Leichter, J. (1986) Effect of chronic alcohol ingestion of fecal and urinary excretion of calcium and magnesium in a rat. Drug-Nutr Interact 4(3): 285-288.

Leitersdorf E. Cholesterol absorption inhibition: filling an unmet need in lipid-lowering management. Eur Heart J Supplements. Vol 3 (Suppl) 2001

Levin, B. E. and A. A. Dunn-Meynell. Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats. Am.J.Physiol Regul.Integr.Comp Physiol 279: R2222-R2228, 2000.

McClain, R. M., Rohrs, J. M. (1985) Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet. Toxicol Appl Pharmacol 77(1): 86-93.

McGivern, R. F., Holcomb, C., Poland, R. E. (1987) Effects of prenatal testosterone propionate treatment on saccharin preference of adult rats exposed to ethanol in utero. Physiol Behav 39(2): 241-246.

McVaugh, W., Lawrence, B., Kulkarni, A., Pizzini, R., Van Buren, C., Rudolph, F., Wolinsky, I., Dafny, N. (1989) Suppression of opiate withdrawal by cyclosporin A and dietary modification. Life Sci 44(14): 977-983.

Nobrega, J. N., Coscina, D. V. (1987) Effects of chronic amitriptyline and desipramine on food intake and body weight in rats. Pharmacol Biochem Behav 27(1): 105-112.

Orthen-Gambill, N. (1985) Sucrose intake unaffected by fenfluramine but suppressed by amphetamine administration. Psychopharmacology 87(1): 25-29.

Plata-Salaman CR, Peloso E, & Satinoff E. Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44):R1353-R1357, 1998.

Robison, W. G. Jr., Laver, N. M., Jacot, J. L., Chandler, m. L., York, B. M., Glover, J. P. (1997) Efficiency of treatment after measurable diabeticlike retinopathy in galactose-fed rats. Invest Ophthalmol Vis Sci 38(6): 1066-1073.

Sahu, A., Phelps, C. P., White, J. D., Crowley, W. R., Kalra, S. P., Kalra, P. S. (1992) Steroidal regulation of hypothalmic neuropeptide Y release and gene expression. Endocrinology 130(6): 3331-3336.

Schnur, P., Martinez, R. A. (1989) Environmental control of morphine tolerance in the hamster. Animal Learning and Behavior 17(3): 322-327.

Semafuko, W. E. B., Rutledge, C. O., Dixon, W. R. (1987) Effect of dietary lipids on myocardial norepinephrine content and field stimulation-mediated release of norepinephrine from perfused neonatal and adult rat hearts. J Cardiovasc pharmacol 10(1): 16-23.

Semafuko, W. E. B., Rutledge, C. O., Dixon, W. R. (1989) Modulation of adrenergic neurotransmission in the rat tail artery by dietary lipids. J Cardiovasc pharmacol 13(1): 138-145.

Shapiro ME, et al. (Metabolic Disease Research, Abbott Laboratories) Effects of Treatment of C57BL/6j Mice Fed High vs. Low Fat Diets with Metformin or Rosiglitazone on Adiposity, Food Intake, Hyperglycemia and Insulin Resistance .Endocrine Society Annual Meeting 2001, Poster Session.

Shepherd J. The role of the exogenous pathway in hypercholesterolemia. Eur Heart J Supplements. Vol.3 (Suppl) 2001

Smeds, S., Wollman, S. H. (1983) Capillary endothelial cell multiplication in adipose tissue pads on the thyroid during the feeding of thiouracil. Endocrinology 112(5): 1718-1722.

Smith, S. B., Cooke, C. B., Yielding, K. L. (1988) Effects of the antioxidant butylated hydroxytoluene BHT on retinal degeneration induced transplacentally by a single low dosage of N methyl-N-nitrosourea MNU. Teratog Carcinog Mutagen 8(4): 175-190.

Smith, S. B., Cooke, C. B., Yielding, K. L. (1989) The antioxidant butylated hydroxytoluene can retard cerebellar. Teratog Carcinog Mutagen 9(1): 15-28.

Stein E. Results of phase I/II clinical trials with ezetimibe, a novel selective cholesterol absorption inhibitor. Eur Heart J Supplements. Vol 3 (Suppl) 2001

Surwit RS, et al. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem.. 1996; 271:9437-40.

Tannenbaum, G. S., Gurd, W., Lapointe, M., Pollak, M. (1992) Tamoxifer attenuates pulsatile growth hormone secretion: Mediation in part by somatostatin. Endocrinology 130(6): 3395-3401.

Tanswell, A. K., Freeman, B. A. (1984) Pulmonary antioxidant enzyme maturation in the fetal and neonatal rat. 18(9): 871-874.

Tepper, B. J., Kanarek, R. B. (1984) 2-DG-induced glucopenia does elicit feeding in rats with lesiums of the zona incerta. Physiol Behav 32(3): 441-446.

Tyan, M. L. (1992) Effects of H-2 and vitamin A on micrognathia in congenic mice. Proc Soc Exp Biol Med 200(3): 418-421.

Tyan, M. L. (1995) Effects of vitamin A and inositol on term weights of H-2 congenic mice. Proc Soc Exp Biol Med 210(1): 77-80.

Tyan, M. L., Tyan, D. B. (1993) Vitamin A-enhanced cleft palate susceptibility gene maps between C4 and B144 within the H-2 complex. Proc Soc Exp Biol Med 202(4): 482-486.

van Heek M, Austin TM, Farley C, Cook JA, Tetzloff GG & Davis HR. Ezetimibe, a Potent Cholesterol Absorption Inhibitor, Normalizes Combined Dyslipidemia in Obese Hyperinsulinemic Hamsters. Diabetes. 50:1330-1335. 2001

van Heek M, Compton DS & Davis HR. The cholesterol absorption inhibitor, ezetimibe, decreases diet-unduced hypercholesterolemia in monkeys. European Journal of Pharmacology. 415: 79-84. 2001

van Heek M, Farley C, Compton DS, Hoos L & Davis HR. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. BJP. 134:409-417. 2001

van Heek M, France CF, Compton DS, Mcleod RL, Yumibe NP, Alton KB, Sybertz EJ & Davis HR. In Vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH48461. JPET. 283: 157-163. 1997

Velazoquez, H., Ellison, D. H., Wright, F. S. (1992) Luminal influences on potassium secretion: Chloride, sodium and thiazide diuretics. American J of Physiology 262(6), Part 2: F1076-1082.

Wainfan, E., Dizik, M., Kilkenny, M., O'Callaghan, J. P. (1990) Prolonged survival of female AKR mice fed diets supplemented with methionine and choline. Carcinogenesis (Lond) 11(3): 361-364.

Wainfan, E., Dizik, M., Lindsley, F. (1987) Suppression by methionine and choline of onco-fetal patterns of liver transfer RNA methyltransferase activities in carcinogen-treated rats. Carcinogenesis (Lond) 8(4): 615-618.

Watson P, Commins S, Beiler R, Hatcher H & Gettys T. Differential regulation of leptin expression and function an A/J vs C57BL/6J mice during diet-induced obesity.Am J Physiol Endocrinol Metab. 2000: 279; E356-365.

Weiss D, Kools JJ, and Taylor WR. Angiotensin II-Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice. Circulation 103: 448-454, 2001.

West, K. L. et al. SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs. Atherosclerosis 171:201–210, 2003.

Wince, L. C., Hugman, L. E., Chen, W. Y., Robbins, R. K., Brenner, G. E. (1987) Effect of dietary lipids on inotropic responses of isolated rat left atrium attenuation of maximal responses by an unsaturated fat diet. J Pharmacol Exp Ther 241(3): 838-845.

Yang, M. T., Yan, L., Pan, Y. W., Liu, Y. L., Yang, S. P. (1986) Effects of molybdenum and tungsten supplementation on female rats fed AIN-76A or Purina Lab Chow. American J of Clinical Nutrition 43(6): no pagination.