A representative listing of journal articles and other published research reporting how diet formulas have been used in research.
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Ahrιn B, et al. Plasma leptin and insulin in C57Bl/6J mice on a high-fat diet: relation to subsequent changes in body weight. Acta Physiol. Scand. 1999;165:233-40. |
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Bachman ES, Dhillon H, Zhang C, Cinti S, Bianco AC, Kobilka BK & Lowell BB.ίAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance. Science. 297:843-845. 2002 |
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Bagnasco, M., M. G. Dube, A. Katz, P. S. Kalra, and S. P. Kalra. Leptin Expression In Hypothalamic Pvn Reverses Dietary Obesity And Hyperinsulinemia But Stimulates Ghrelin. Obes Res. 11:14631470, 2003. |
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Bartness, R. J., Bittman, E. L., Wade, G. N. (1985) Paraventricular nucleus lesions exaggerate dietary obesity but block photoperiod-induced weight gains and suspension of estrous cyclicity in syrian hamsters. Brain Res Bull 14(5): 427-430. |
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Bartness, T. J., Bittman, E. L., Wade, G. N. (1985) Paraventricular nucleus lesions exaggerate dietary obesity but block photoperiod-induced weight gains and suspension of estrous cyclicity in syrian hamsters. Brain Res Bull 14(5): 427-430. |
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Bizeau ME, Short C, Thresher JS, Commerford SR, Willis WT, & Pagliossotti MJ. Increased pyruvate flux capacities account for diet-induced increases in gluconeogenesis in vitro. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R427-R433, 2001. |
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Bluher, S., Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice. Diabetes 53:8290, 2004. |
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Brunengraber, D. Z., et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. Am J Physiol Endocrinol Metab 285: E917E925, 2003. |
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Bunag, R. D., Krizsan, D., Itoh, H. (1990) Diminished cardiovascular responsiveness to vagalstimulation in obese rats. American J of Physiology 259(4): R842-848. |
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Castonguay, T. W., Dallman, M. F., Stern, J. S. (1986) Some metabolic and behavioral effects of adrenalectomy on obese Zucker rats. American J of Physiology 251(4): R923-933. |
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Commerford SR, Pagliossotti MJ, Melby CL, Wei Y, & Hill JO. Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:R1680-R1687, 2001. |
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Commerford SR, Pagliossotti MJ, Melby CL, Wei Y, Gayles EC, & Hill JO. Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats. Am. J. Physiol. Endocrinol. Metab. 279:E875-E885, 2000. |
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Conarello, S. L., et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. PNAS, 100:11: 68256830, 2003. |
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Dhar, M. S., et al. Mice Heterozygous for Atp10c, a Putative Amphipath, Represent a Novel Model of Obesity and Type 2 Diabetes. J. Nutr. 134: 799805, 2004. |
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Dobrian AD, Davies MJ, Prewitt RL, & Lauterio TJ. Development of hypertension in a rat model of diet-induced obesity. Hypertension. 2000; 35:1009-15. |
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Dobrian AD, Davies MJ, Schriver SD , Lauterio TJ, & Prewitt RL. Oxidative stress in a rat model of obesity-induced hypertension. Hypertension 2001; 37:554-560. |
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Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS & Kalra SP. Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemeia, and Hyperinsulinemia. Diabetes 51:1729-1736, 2001. |
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El-Haschimi K, et al. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J.Clin.Invest. 2000; 105:1827-1832. |
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Farley, C., J. A. Cook, B. D. Spar, T. M. Austin, and T. J. Kowalski. Meal Pattern Analysis Of Diet-Induced Obesity In Susceptible And Resistant Rats. Obes Res. 11:845851, 2003. |
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Felipe, F., M.L. Bonet, J. Ribot and A. Palou. Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment. International Journal of Obesity 27: 6069, 2003. |
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Fisher H., Halladay A., Ramasubramaniam N., Petrucci J.C., Dagounis D., Sekowski A., Martin J.V., & Wagner G.C. Liver Fat and Plasma Ethanol Are Sharply Lower in Rats Fed Ethanol in Conjunction with High Carbohydrate Compared with High Fat Diets. J. Nutr. 132: 2732-2736. 2002 |
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Fu, J., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR. Nature 425:90-93, 2003. |
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Gao, J., L. Ghibaudi, M. Van Heek, J. J. Hwa. Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Research 936:8790, 2002. |
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Gavrilova, O., et al. Liver Peroxisome Proliferator-activated Receptor Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass. The Journal of Biological Chemistry 278:36:3426834276, 2003. |
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Gayles EC, Pagliassotti MJ, Prach PA. Koppenhafer TA, & Hill JO. Contribution of energy intake and tissue enzymatic profile to body weight gain in high-fat-fed rats. Am. J. Physiol. 272:R188-R194, 1997. |
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Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J. Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats. Obes. Res. 10:956-963. 2002 |
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Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J.Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats. Obes. Res. 10:956-963. 2002 |
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Hancock, A.A. et al. Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. European Journal of Pharmacology 487:183197, 2004. |
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Harris RBS, Mitchell TD, & Hebert S (Pennington Biomedical Research Center, Baton Rouge, LA). Leptin-Induced Changes in Body Composition in High Fat-Fed Mice. AJP-Regul Integr Comp Physiol 284:R87-R100, 2003. |
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Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology 462:125132, 2003. |
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Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolution X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and Toxicological Methods 47: 99 106, 2002. |
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Hileman, S. M., D.D. Pierroz, H. Masuzaki, C. Bjψrbζk, K. El-Haschimi, W. A. Banks, and J. S. Flier. Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity. Endocrinology 143:775783, 2002. |
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Ho, A., Chin, A. (1988) Circadian feeding and drinking patterns of genetically obese mice fed solid chow diet. Physiol Behav 43(5): 651-656. |
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Ishii, M., H. Fei, and J. M. Friedman. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. PNAS 100:18:1054010545, 2003. |
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Joseph, J. W., V. Koshkin, C-Y Zhang, J. Wang, B. B. Lowell, C. B. Chan, and M.B. Wheeler. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet. Diabetes 51:32113219, 2002. |
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Keenan, K. P. (1998) Effects of diet and overfeeding on body weight and survival in the rodent bioassay: The impact on pharmaceutical safety assessment. International Journal of Toxicology 17: 101-117. |
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Keenan, K. P., Ballam, G. C., Dixit, R., Soper, K. A., Laroque, P., Mattson, B. A., Adams, S. P., Coleman, J. B. (1997) The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, discease and toxicology. Journal of Nutrition 127(5): 851S-856S. |
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Keenan, K. P., Laroque, P., Ballam, G. C., Soper, K. A., Dixit, R., Mattson, B. A., Adams, S. P., Coleman, J. B. (1996) The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment. Toxicologic Pathology 24(6): 757-768. |
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Keenan, K. P., Laroque, P., Coleman, J. B., Cook, W. O., Dixit, R., Soper, B. A., Mattson, K. A., Ballam, G. C. (1996) The subchronic effects of ad libitum overfeeding and moderate or marked dietary restriction (DR) on biomarkers of longevity, degenerative disease, and carcinogenesis in the Sprague-Dawley rat. Toxicologic Pathology 24(6): 788. |
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Keenan, K. P., Laroque, P., Soper, K. A., Morrissey, R. E., Dixit, R. (1996) The effects of overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, pathology, carcinogenicity, and the toxicity of pharmaceutical agents. Exp Toxicologic Pathology 48(2-3): 139-144. |
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Keenan, K. P., Smith, P. F., Hertzog, P., Soper, K., Ballam, G. C., Clark, R. L. (1994) The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging. Toxicologic Pathology 22(3): 300-315. |
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Keenan, K. P., Soper, K. A., Hertzop, P. R., Gumprecht, L. A., Smith, P. F., Mattson, B. A., Ballam, G. C., Clark, R. L. (1995) Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions. Toxicologic Pathology 23(3): 287-302. |
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Keenan, K. P., Soper, K. A., Smith, P. F., Ballam, G. C., Clark, R. L. (1995) Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms. Toxicologic Pathology 23(3): 269-286. |
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Kumar, M. V., T. Shimokawa, T. R. Nagy, and M. D. Lane. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. PNAS 99:4: 19211925, 2002. |
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Lambert, P. D., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. PNAS 98:8: 46524657, 2001. |
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Laroque, P. A., Hubert, M-F., Keenan, K. P., Duprat, P. (1996) The effects of ad libitum overfeeding and moderate or severe dietary restriction on spontaneous degenerative and proliferative lesions in Sprague-Dawley rats. Toxicologic Pathology 24(6): 787. |
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Lauterio TJ, Barkan A, DeAngelo M, DeMott-Friberg R, & Ramirez R. Plasma growth hormone secretion is impaired in obesity-prone rats before onset of diet-induced obesity. Am. J. Physiol. 1998; 275:E6-11. |
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Lauterio TJ, Davies MJ, DeAngelo M, Peyser M, & Lee J. Neuropeptide Y Expression and Endogenous Leptin Concentration in a Dietary Model of Obesity. Obes. Res.. 1999; 7:498-505. |
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Lauterio TJ, et al. Development and characterization of a purified diet to identify obesity-susceptible and resistant rat populations. J. Nutr. 1994; 124:2172-2178. |
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Le Laya, S., et al. Decreased Resistin Expression in Mice with Different Sensitivities to a High-Fat Diet. Biochemical and Biophysical Research Communications 289:2:564-567, 2001. |
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Levin BE, et al. (1987) Glucose-induced norepinephrine levels and obesity resistance. Am J Phys.253(3 Pt 2):R475-81. |
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Levin BE, et al. Resistance to diet-induced obesity: food intake, pancreatic sympathetic tone, and insulin. Am. J. Phys.252(3 Pt 2):R471-R478, 1987. |
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Levin, B. E. and A. A. Dunn-Meynell. Defense of body weight against chronic caloric restriction in obesity- prone and -resistant rats. Am.J.Physiol Regul.Integr.Comp Physiol 278: R231-R237, 2000. |
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Levin, B. E. and A. A. Dunn-Meynell. Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am.J.Physiol Regul.Integr.Comp Physiol 282: R46-R54, 2002. |
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Levin, B. E. and A. A. Dunn-Meynell. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet- induced obese rats. Am.J.Physiol 272: R1365-R1370, 1997. |
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Levin, B. E. and A. A. Dunn-Meynell. Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats. Am.J.Physiol Regul.Integr.Comp Physiol 279: R2222-R2228, 2000. |
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Levin, B. E. and E. Govek. Gestational obesity accentuates obesity in obesity-prone progeny. Am.J.Physiol 275: R1374-R1379, 1998. |
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Levin, B. E. and R. E. Keesey. Defense of differing body weight set points in diet-induced obese and resistant rats. Am.J.Physiol 274: R412-R419, 1998. |
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Levin, B. E. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am.J.Physiol 276: R382-R387, 1999. |
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Levin, B. E. Reduced norepinephrine turnover in organs and brains of obesity-prone rats. Am.J.Physiol 268: R389-R394, 1995. |
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Levin, B. E., A. A. Dunn-Meynell, B. Balkan, and R. E. Keesey. Selective breeding for diet-induced obesity and resistance in Sprague- Dawley rats. Am.J.Physiol 273: R725-R730, 1997. |
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Levin, B. E., D. Richard, C. Michel, and R. Servatius. Differential stress responsivity in diet-induced obese and resistant rats. Am.J.Physiol Regul.Integr.Comp Physiol 279: R1357-R1364, 2000. |
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Levin, B. E., E. K. Govek, and A. A. Dunn-Meynell. Reduced glucose-induced neuronal activation in the hypothalamus of diet- induced obese rats. Brain Res. 808: 317-319, 1998. |
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Levy JR, Lesko J, Krieg RJ, Adler RA & Stevens W. Leptin responses to glucose infusions in obesity-prone rats. Am J Physiol Endocrinol Metab 2000; 279:E1088-1096. |
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Ludwig, D. S., et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 107:379386, 2001. |
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Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001; 294:2166-2170. |
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Moon, Y. S., et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity. Molecular And Cellular Biology 22:15: 55855592, 2002. |
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Morin CL, Eckel RH, Marcel T, & Pagliassotti MJ. High fat diets elevate adipose tissue-derived tumor necrosis factor- alpha activity. Endocrinology 138:4665-4671, 1997. |
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Morton, J. L., Davenport, M., Beloff-Chain, A., Bodkin, N. L., Hansen, B. C. (1992) Correlation between plasma beta cell tropin concentrations and body weight in obese Rhesus monkeys. American J of Physiology 262(6), Part 1: E963-967. |
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Murray I, Havel PJ, Sniderman AD & Cianflone K. Reduced Body Weight, Adipose Tissue, and Leptin Levels Despite Increased Energy Intake in Female Mice Lacking Acylation-Stimulating Protein. Endocrinology. 141:1041-1049; 2000 |
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O'Brien, D. W. (1981) The effect of prolonged physical training and high fat diet on heart size and body weight in rats. Can J Physiol Pharmacol 59(3): 268-272. |
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Oscai, L. B., Brown, M. M., Miller, W. C. (1984) Effect of dietary fat on food intake growth and body composition in rats. Growth 48(4): 415-424. |
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Oscai, L. B., Miller, W. C. (1986) Dietary-induced severe obesity exercise implications. Med Sci Sports Exercise 18(1): 6-9. |
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Oscai, L. B., Miller, W. C., Arnall, D. A. (1987) Effects of dietary sugar and of dietary fat on food intake and body fat content in rats. Growth 51(1): 64-73. |
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Pagliassotti MJ, Horton T J, Gayles EC, Koppenhafer TA, Rosenzweig TD, and. Hill JO. Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats. Am.J.Physiol 272: R1264-R1270, 1997. |
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Pagliassotti MJ, Knobel SM, Shahrokhi KA, & Hill JO. Time course of adaptation to a high-fat diet in obesity-resistant and obesity-prone rats. Am. J. Physiol. 267:R659-R664, 1994 |
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Pagliassotti MJ, Shahrokhi KA, & Hill JO. Skeletal muscle glucose metabolism in obesity-prone abd obesity-resistant rats. Am. J. Physiol. 264:R1224-R1228, 1993. 7. |
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Pagliassotti, M et al. Tissue oxidative capacity, fuel stores and skeletal muscle fatty acid composition in obesity-prone and obesity-resistant rats. Obes. Res. 3:459-64, 1995. |
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Parkinson, W. L., Weingarten, H. P. (1990) Dissociative analysis of ventromedial hypothalmic obesity syndrome. American J of Physiology 259(4): R829-835. |
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Pierroz, D. D., M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S. Mantzoros. Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes 51:13371345, 2002. |
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Plata-Salaman CR, Peloso E, & Satinoff E. Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44):R1353-R1357, 1998. |
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Podolin DA, Wei Y, & Pagliassotti MJ. Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats. J. Appl. Physiol. 86(4):1374-1380, 1999. |
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Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks LA, Scherer PE, Lisanti MP. Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J Biol. Chem., Mar 2002; 277: 8635 - 8647 ; 10.1074/jbc.M110970200 |
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Scrocchi LA & Drucker DJ. Effects of Aging and a High Fat Diet on Body Weight and Glucose Tolerance in Glucagon-Like Peptide-1 Receptor -/- Mice. Endocrinology 139:3127-3132, 1998. |
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Shklyaev, S., et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. PNAS 100:24:1421714222, 2003. |
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Sinha, Y., Thomas, J., Salocks, C., Wickes, M., Vanderlaan, W. (1977) Prolactin and growth hormone secretion in diet-induced obesity in mice. Horm Metab Res 9(4): 277-282. |
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Smagin GN, Howell LA, Redmann S, Ryan DH, & Harris RBS. Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist. Am J Physiol. 276: R1461-R1468. 1999 |
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Surwit RS, Dixon T, Petro A, Daniel K & Collins S. Diazoxide Restores Beta-three Adrenergic Receptor Function in Diet-Induced Obesity and Diabetes. Endocrinol. 2000: 141; 3630-3637 |
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Surwit RS, et al. Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Metabolism.. 1998;47:1354-9. |
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Surwit RS, et al. Differential Effects of Fat and Sucrose on the Development of Obesity and Diabetes in C57BL/6J and A/J Mice. Metabolism. 1995; 44:645-651. |
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Surwit RS, et al. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem.. 1996; 271:9437-40. |
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Surwit RS, et al. Reversal of diet-induced obesity and diabetes in C57BL/6J mice. Metabolism.. 1998;47:1089-96. |
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Takahashi, N., et al. Divergent Effects of Leptin in Mice Susceptible or Resistant to Obesity. Horm Metab Res 34:691-697, 2002. |
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Tang H, Vasselli JR, Wu EX, Boozer CN, & Gallagher D. High-Resolution Magnetic Resonance Imaging Tracks Changes in Organ and Tissue Mass in Obese and Aging Rats. Am J Physiol (Regulatory Integrative Comp Physiol) 282:R890-R899, 2002. |
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Thupari, J. N., L. E. Landree, G. V. Ronnett, and F. P. Kuhajda. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. PNAS 99:14:94989502, 2002. |
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Tortoriello, D. V., J. Mcminn, and S. C. Chua. Dietary-Induced Obesity and Hypothalamic Infertility in Female DBA/2J Mice. Endocrinology 145: 12381247, 2004. |
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Triscari, J., Nauss-Karol, C., Levin, B. E., Sullivan, A. C. (1985) Changes in lipid metabolism in diet-induced obesity. Metab Clin Exp 34(6): 580-587. |
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Tulp, O. L., Stevens, C., Barbie, O. A. (1989) Non-shivering thermogenesis and obesity in adult diabetic Wistar fatty rats. Comp Biochem Physiol A Comp Physiol 92(1): 37-42. |
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Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA, Cinti S, Lafontan M, and Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. J.Biol.Chem. 275: 34797-34802, 2000. |
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Van Heek M, Austin TM, et al. Rhesus monkeys develop variable obesity and metabolic profiles after chronic consumption of a high fat Western diet. |
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Van Heek M, et al. Diet-induced Obese Mice Develop Peripheral, but not Central Resistance to Leptin. J. Clin. Invest. 1997; 99:385-390. |
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Watson P, Commins S, Beiler R, Hatcher H & Gettys T. Differential regulation of leptin expression and function an A/J vs C57BL/6J mice during diet-induced obesity.Am J Physiol Endocrinol Metab. 2000: 279; E356-365. |
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Weigle, D. S. and B. E. Levin. Defective dietary induction of uncoupling protein 3 in skeletal muscle of obesity-prone rats. Obes.Res. 8: 385-391, 2000. |
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Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112:17961808, 2003. |
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West DB, Delany JP, Camet, PM, Blohm F, Truett AA, & Scimeca J. Effects of conjugated lineolic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. 1998; 276:R1172-R1179 (Regulatory Integrative Comp. Physiol. 45). |
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West, D. B., Boozer, C. N., Moody, D. L., Atkinson, R. L. (1992) Dietary obesity in nine inbred mouse strains. American J of Physiology 262(6), Part 2: R1025-1032. |
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Xu, H. et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:18211830, 2003. |
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Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am. J. Physiol. Endocrinol. Metab. 279:E383-E845, 2000. |